Androgen insensitivity syndrome is an intersex condition in which a person who is genetically male is resistant to male hormones . As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man.
The SRY gene is involved in male sexual development—without it fetuses can be genetically male (with XY chromosomes) but have a female body. The same is true in females (with XX chromosomes), who can develop a male body without the SRY gene.
XXY males are sterile, with small testes—while women with only one X chromosome (a condition called Turner syndrome) are infertile and don’t go through puberty. Males with two X chromosomes (called Klinefelter syndrome) are taller, with a higher risk of breast cancer and osteoporosis.